BIO-EQUIVALENCE
AUC
of the plasma concentration time curves of same drug X, but of different oral
formulations A, B and C, are almost same.
So
the extent of absorption of the three formulations are same.
However,
they are not bio-equivalent.
Reason-
The rate of absorption is not same.
For
bio-equivalence, both rate and extent of absorption should not be significantly
different.
AUC
for A and B are similar with respect to both the rate and extent of absorption.
AUCs are similar in shape and size. Therefore, formulations A and B are
bio-equivalent.
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