Dose-response curve is graphed by plotting the response obtained against incremental doses of the administered drug. Dose response is of two types- graded and quantal.
- Graded dose-response curve:
- A Graded dose-response curve plots the drug effect which proportionately increase with the increase of drug dose.
- Such a response to a drug can be seen only in an individual subject or animal or an experimental set up.
- Since the plasma concentration of drugs varies as a function of the dose, graded dose-response curve is equivalent to plasma concentration-response curve.
- Quantal dose-response curve:
- A Quantal dose-response curve describes a drug effect which is binary (either present or absent) (ie whether an event has occurred or not)
- A quantal response to a drug is obtained by quantifying the percent of the total population in which response is seen at a specific drug dose. eg The plot of the proportion of patients cured of an infection against the increasing dose dose of an antibiotic
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