Factors affecting bio-availability
1. First pass metabolism- reciprocal relation between first pass metabolism and bio-availability
2. Pharmaceutical properties of the drug- water/lipid solubility, pKa of the drug, molecular weight etc
3. Rate of dissolution of the drug formulation
4. Gastric and intestinal transit time.
5. Hepatic function- Normal or impaired
6. Age
7. Drug-drug interaction
8. Drug-food interaction
9.Route of administration
10. Enzyme induction/inhibition
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