Anti-diuretic action of thiazides is secondary to increased renal sodium excretion.
👉Thiazide diuretics inhibit the NaCl co-transporter in the renal distal convoluted tubule
👉 Initially, this increases renal sodium loss in the urine
👉 The renal sodium loss causes extracellular volume contraction
👉 This leads to decrease in GFR.
👉In response, there is increased proximal tubular sodium and water re-absorption.
👉 Therefore, less water and solutes are delivered to the distal tubule and collecting duct
👉 So, finally, there is less loss of water and solutes in the urine
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