Thursday, August 12, 2021

 Measures/Indices of Bio-availability

Absolute Bio-availability

The systemic availability of a drug by any route compared to the intravenous route.

Relative Bio-availability

The systemic availability of a drug by any route compared to its standard formulation. It is also known as bio-equivalence.


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Lidocaine and phenytoin- both are sodium channel blockers. Lidocaine is a local anaesthetic and an anti-arrhythmic. Phenytoin is an anticonvulsant. What explains their differential action? Is it because of their difference in pharmacokinetics.

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