BOOSTED PI REGIMEN:
AN EXAMPLE OF ENZYME INHIBITION USED FOR THERAPEUTIC PURPOSE
Protease inhibitors (PIs) are a class of anti-HIV drugs
PIs have high first pass metabolism. They are mainly metabolised by CYP3A4
PIs when indicated, have to be given as 6-18 tablets daily for months. Patient acceptability and compliance are low.
Ritonavir is also a PI which is a CYP3A4 inhibitor.
Low dose of ritonavir in patients receiving PI based regimen, reduces first pass metabolism of the PIs.
Therefore, the dose of PIs can be reduced and the number and frequency of tablets can also be reduced. The side effects are also reduced.
This provides some relief to the people living with HIV infection receiving PI regimen.
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