Aspirin is a drug with multiple uses. At low dose, it is used as an anti platelet. It has analgesic, anti-pyretic and anti-inflammatory actions in a wide dose range. However, aspirin is not the drug choice for fever in any age group. Paracetamol is considered safer. In children, it is more true because aspirin has been found to be associated with Reye’s syndrome when used as antipyretic in children suffering from chickenpox, influenza and other viral illness. In such illness, aspirin may cause hepatic mitochondrial damage. There is inhibition of fatty acid metabolism and increase in serum ammonia levels. Hyperammonemia may induce diffuse cerebral edema and raised intracranial pressure. The child presents with profuse vomiting, stupor which may rapidly progress to coma, cardio respiratory failure and death.
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Lidocaine and phenytoin- both are sodium channel blockers. Lidocaine is a local anaesthetic and an anti-arrhythmic. Phenytoin is an anticonvulsant. What explains their differential action? Is it because of their difference in pharmacokinetics.
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What's the "FUZZ" about drug promotional literature. Are FDCs of Iron with multivitamins rational???π¦ Iron is given for iron deficiency anaemia. π¦ In this condition, there is no role of other vitamins unless and untill there is a concurr...
Well written sirπ
ReplyDeleteinformative and useful
ReplyDelete,ππ
ReplyDeleteExcellent Dr Shanwaj bhi
ReplyDeleteSunil Kumar ( AIIMS)
Excellent sirπ
ReplyDeleteNice explanation Sir ππ
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