Friday, January 28, 2022

The electrophysiology of cardiac action potential in non-pacemaker cells: watch the video

 The “heart” of the functioning of the heart is the fast cell to cell communication between the cardiac myocytes. Upon generation of the pacemaker potential, the impulse is transmitted electrically to the adjacent cells. An action potential begins with rapid firing of fast Na+ channels resulting in rapid depolarisation (phase 0), following which there is an early repolarisation (phase 1). In the phase 2, Ca++ moves into the cells triggering massive release of calcium from the endoplasmic reticulum. And the cell contracts...

Delve into the depths of the molecular mechanism of the cardiac action potential. Click the 

https://youtu.be/tHttyFRjddM

1 comment:

Lidocaine and phenytoin- both are sodium channel blockers. Lidocaine is a local anaesthetic and an anti-arrhythmic. Phenytoin is an anticonvulsant. What explains their differential action? Is it because of their difference in pharmacokinetics.

 Drugs, more than often, have multiple actions. The ability of drugs to interact with different targets and sometimes same target in differe...